| Injuries | ||||||
| Duration | ||||||
| Date | Team | Name | Cause | Return | Orig | Left |
| 8/5/1921 | Cal | Williams,C | Collision on bases | 8/13/1921 | 8 | 1 |
| 7/29/1921 | Gal | Wilkinson | General | 8/14/1921 | 16 | 2 |
| 8/4/1921 | Top | Ryan | General | 8/15/1921 | 11 | 3 |
| 8/12/1921 | Mac | Foster | General | 8/17/1921 | 5 | 5 |
| 8/10/1921 | BG | Milan | General | 8/17/1921 | 7 | 5 |
| 8/1/1921 | BG | Naylor | General | 8/17/1921 | 16 | 5 |
| 8/8/1921 | Tex | Benton | General | 8/18/1921 | 10 | 6 |
| 8/4/1921 | OL | Wingo | General | 8/18/1921 | 14 | 6 |
| 7/20/1921 | Mac | Ehmke | General | 8/20/1921 | 31 | 8 |
| 8/10/1921 | Top | Wambsganss | General | 8/23/1921 | 13 | 11 |
| 8/12/1921 | Wil | Vangilder | General | 8/26/1921 | 14 | 14 |
| 8/12/1921 | Top | Burns,GH | General | 8/28/1921 | 16 | 16 |
| 8/12/1921 | Mid | Kolp | General | 8/28/1921 | 16 | 16 |