| Transactions | ||||||
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/18/1921 | Gal | Keen | Promoted to active roster | Before | ||
| 4/18/1921 | Gal | Miller,RH | Demoted to reserve roster | Before | ||
| 4/18/1921 | Gal | Townsend,L | Demoted to reserve roster | Before | ||
| 4/18/1921 | Gal | Yellow Horse | Promoted to active roster | Before | ||
| 5/17/1921 | Mid | Maisel | Traded away | OL | After | |
| 5/17/1921 | Mid | Sallee | Acquired via trade | OL | After | |
| 6/23/1921 | Tex | Hanson | Promoted to active roster | Before | ||
| 6/23/1921 | Tex | Walsh | Demoted to reserve roster | Before | ||
| 6/28/1921 | Mid | Mamaux | Traded away | Aus | After | |
| 6/28/1921 | Mid | Miljus | Traded away | Aus | After | |
| 6/28/1921 | Mid | Riviere | Acquired via trade | Aus | After | |
| 6/28/1921 | Mid | Wieneke | Acquired via trade | Aus | After | |
| 7/1/1921 | Alt | Jones,S | Traded away | DBL | After | |
| 7/1/1921 | Alt | Roush | Traded away | DBL | After | |
| 7/1/1921 | Alt | Ward,A | Traded away | DBL | After | |
| 7/1/1921 | Bla | Johnston,J | Traded away | DBL | After | |
| 7/1/1921 | Bla | Ruth | Traded away | DBL | After | |
| 7/1/1921 | Gal | Glazner | Traded away | DBL | After | |
| 7/1/1921 | Gal | Mogridge | Traded away | DBL | After | |
| 7/1/1921 | Gal | Perkins | Traded away | DBL | After | |
| 7/1/1921 | Gal | Shea | Traded away | DBL | After | |
| 7/1/1921 | KS | Faber | Traded away | DBL | After | |
| 7/1/1921 | KS | Wrightstone | Traded away | DBL | After | |
| 7/1/1921 | Mac | Meusel,B | Traded away | DBL | After | |
| 7/1/1921 | Mac | Sisler | Traded away | DBL | After | |
| 7/1/1921 | Mid | Hawks | Traded away | DBL | After | |
| 7/1/1921 | Mid | Veach | Traded away | DBL | After | |
| 7/1/1921 | NO | Smith,El | Traded away | DBL | After | |
| 7/1/1921 | Tex | Bancroft | Traded away | DBL | After | |
| 7/1/1921 | Tex | Gardner | Traded away | DBL | After | |
| 7/1/1921 | Tex | Powell | Traded away | DBL | After | |
| 7/1/1921 | Tex | Schang | Traded away | DBL | After | |
| 7/4/1921 | Alt | Jones,S | Acquired via trade | DBL | After | |
| 7/4/1921 | Alt | Roush | Acquired via trade | DBL | After | |
| 7/4/1921 | Alt | Ward,A | Acquired via trade | DBL | After | |
| 7/4/1921 | Bla | Johnston,J | Acquired via trade | DBL | After | |
| 7/4/1921 | Bla | Ruth | Acquired via trade | DBL | After | |
| 7/4/1921 | Gal | Glazner | Acquired via trade | DBL | After | |
| 7/4/1921 | Gal | Mogridge | Acquired via trade | DBL | After | |
| 7/4/1921 | Gal | Perkins | Acquired via trade | DBL | After | |
| 7/4/1921 | Gal | Shea | Acquired via trade | DBL | After | |
| 7/4/1921 | KS | Faber | Acquired via trade | DBL | After | |
| 7/4/1921 | KS | Wrightstone | Acquired via trade | DBL | After | |
| 7/4/1921 | Mac | Meusel,B | Acquired via trade | DBL | After | |
| 7/4/1921 | Mac | Sisler | Acquired via trade | DBL | After | |
| 7/4/1921 | Mid | Hawks | Acquired via trade | DBL | After | |
| 7/4/1921 | Mid | Veach | Acquired via trade | DBL | After | |
| 7/4/1921 | NO | Smith,El | Acquired via trade | DBL | After | |
| 7/4/1921 | Tex | Bancroft | Acquired via trade | DBL | After | |
| 7/4/1921 | Tex | Gardner | Acquired via trade | DBL | After | |
| 7/4/1921 | Tex | Powell | Acquired via trade | DBL | After | |
| 7/4/1921 | Tex | Schang | Acquired via trade | DBL | After | |
| 7/12/1921 | KS | Kopf,W | Acquired via trade | BB | After | |
| 7/12/1921 | KS | Thormahlen | Traded away | BB | After | |
| 7/18/1921 | Gal | Yellow Horse | Traded away | BB | After | |
| 7/24/1921 | Bla | Bailey,S | Traded away | Gal | After | |
| 7/24/1921 | Bla | Glazner | Acquired via trade | Gal | After | |
| 7/24/1921 | Bla | Oeschger | Acquired via trade | Gal | After | |
| 7/24/1921 | Bla | Parks | Traded away | Gal | After | |
| 7/24/1921 | Gal | Bailey,S | Acquired via trade | Bla | After | |
| 7/24/1921 | Gal | Glazner | Traded away | Bla | After | |
| 7/24/1921 | Gal | Oeschger | Traded away | Bla | After | |
| 7/24/1921 | Gal | Parks | Acquired via trade | Bla | After | |
| 7/25/1921 | Gal | Gaston | Promoted to active roster | Before | ||
| 3/29/2025 | Alt | Cheeves | Traded away | NO | After | |
| 3/29/2025 | NO | Cheeves | Acquired via trade | Alt | After | |
| 4/5/2025 | Mac | Martin | Acquired via trade | Aus | After | |
| 4/5/2025 | Mac | Schmidt | Acquired via trade | Aus | After | |
| 4/11/2025 | Alt | Cutshaw | Traded away | Aus | After | |
| 4/11/2025 | Alt | Mann | Traded away | Aus | After | |
| 4/11/2025 | Alt | Stock | Acquired via trade | Aus | After | |
| 4/11/2025 | NO | Barnhart | Acquired via trade | Tex | After | |
| 4/11/2025 | NO | Gardner | Traded away | Tex | After | |
| 4/11/2025 | Tex | Barnhart | Traded away | NO | After | |
| 4/11/2025 | Tex | Gardner | Acquired via trade | NO | After | |
| 4/28/2025 | Mac | Bagby | Acquired via trade | Top | After | |
| 4/28/2025 | Mac | McHenry | Traded away | Top | After | |